研究团队 >
教师
籍 贯：江苏 连云港
最后学历：博士
• 研究员；
• 美国糖尿病协会、北美华人糖尿病学会、美国心脏病学会和美国生理学会会员。
研究方向：
重点研究在正常生理情况下和糖尿病发病过程中细胞能量感受（nutrient sensing）和代谢重编程（metabolic reprogramming）的转录调控和信号转导机制，及其在糖尿病发生发展过程中的作用，从而为糖尿病的诊断和治疗提供理论基础和新的药物靶标。
研究成果：
• 揭示了2型糖尿病慢性炎症和糖脂毒性损伤胰岛beta细胞的新的信号通路机制；
• 发现了一条调控骨骼肌白肌能量代谢的重要信号通路，而激活该信号通路增强白肌
的代谢功能，能够预防高脂饮食或者遗传因素引起的肥胖和糖尿病；
• 发现了一条以肝脏中BAF60a及其靶基因CAR为核心分子的调控全身胆固醇稳态的重
要转录通路。
• 以第一作者和共通讯作者身份分别在Nature Medicine、Circulation、Cell Reports、
Di-abetes、Diabetologia 和Endocrinology 等基础医学和糖尿病研究领域的权威杂志
发表多篇高水平论文。
个人成就：
• Diabetologia、Endocrinology、Scientific Reports等多个权威杂志特约申稿人。
• 2015年入选浙江大学“百人计划”，聘为研究员、博士
生导师。
联系方式：
地 址：浙江大学医学院 研究楼
电 话：0571—889981141/18896614886
E-mail：zxmeng@zju.edu.cn
教育经历：
2004/09–2009/07：南京医科大学 生物化学与分子生物学系 博士
1999/09–2004/07：南京医科大学 临床医学系 本科
工作经历：
2016/02月–现 在：浙江大学医学院 病理与病理生理学系 教授/研究员
2014/02月–2016/01：美国密歇根大学 研究员（Research Investigator)
2009/07月–2014/01：美国密歇根大学 博士后
学术荣誉：
2016：首批“浙江大学王宽诚青年学者”
2015：北美华人糖尿病协会杰出研究工作奖（Excellence In Research Award）
2014：江苏省特聘教授
2015：美国心脏病学会科学奖发展奖（Scientist Development Award )
2012：美国心脏病学会博士后奖学金
2010：江苏省优秀博士论文
2009：南京医科大学优秀博士论文
2007：江苏省科技进步二等奖（排名第三）
2004：保送攻读博士学位
学术兼职：
2015−北美华人糖尿病协会会员
2015−美国糖尿病协会会员
2013−美国心脏病协会会员
2012−美国生理学会会员
杂志特约审稿人：
2015− Plos One
2014−Journal of Biological Rhythms
2014−Scientific Reports
2013−Endocrinology
2013−Diabetologia
主要科研项目：
1、浙江大学“百人计划“项目，2016/01-2021/12，300万元，在研，主持。
发表论文：
1）Xu G, Meng ZX, Lin JD, Deng CX, Carson PL, Fowlkes JB, Tao C, Liu X, Wang X (2015) High resolution Physio-chemical Tissue Analysis:
Towards Non-invasive In Vivo Biopsy. Scientific Reports. 2016 Feb 4;6:16937.
2）Meng ZX*, Wang L, Chang L, Sun JX, Bao J, Li Y, Chen YE, Lin JD* (2015) A diet sensitive Baf60a-mediated pathway links bile acid
metabolism to atherosclerosis. Cell Reports. 13: 1-12. *co-corresponding author.
3）Wang GX, Zhao XY, Meng ZX, Kern M, Dietrich A, Chen Z, Cozacov Z, Zhou D, Okunade AL, Su X, Li S, Blüher M, Lin JD (2014) The
brown fat–enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis. Nature Medicine. 20:1436-43.
4）Lu B, Bridges D, Yang Y, Fisher K, Cheng A, Chang L, Meng ZX, Lin JD, Downes M, Yu R, Liddle C, Evans R, Saltiel A (2014) Metabolic
Crosstalk: molecular links between glycogen and lipid metabolism in obesity. Diabetes. 63: 2935-48.
5）Meng ZX, Wang L, Xiao Y, Lin JD (2014) The Baf60c/Deptor Pathway Links Skeletal Muscle Inflammation to Glucose Homeostasis in Obesity.
Diabetes. 63:1533-45.
6）Xu G, Meng ZX, Lin JD, Yuan J, Carson P, Joshi B, and Wang X (2014) The Functional Pitch of An Organ: Quantification of Tissue Texture with
Photoacoustic Spectrum Analysis. Radiology. 271: 248-54.
7）Meng ZX, Li S, Wang L, Ko HJ, Lee Y, Okutsu M, Yan Z, Kim, JK, Lin JD (2013) Baf60c drives glycolytic metabolism in the muscle and
improves systemic glucose homeostasis through Deptor-mediated Akt activation. Nature Medicine. 19: 640-5.
8）Chen XW, Wang H, Bajaj K, Zhang P, Meng ZX, Ma D, Bai Y, Adams E, Baines A, Yu G, Sartor MA, Zhang B, Yi Z, Lin JD, Young S,
Schekman R, Gingsburg D (2013) SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion. Elife. 2: e00444.
9）Meng ZX, Wang GX, Lin JD (2012) A microRNA circuitry links macrophage polarization to metabolic homeostasis. Circulation.125: 2815-7.
10）Meng ZX, Yin Y, Lv JH, Sha M, Lin Y, Gao L, Zhu YX, Sun YJ, Han X (2012) Aberrant activation of liver X receptors impairs pancreatic beta
cell function through upregulation of sterol regulatory element-binding protein 1c in mouse islets and rodent cell lines. Diabetologia.
55: 1733-44.
11）Meng ZX, Lv J, Luo Y, Lin Y, Zhu Y, Nie J, Yang T, Sun Y, Han X (2009) Forkhead box O1/pancreatic and duodenal homeobox 1 intracellular
translocation is regulated by c-Jun N-terminal kinase and involved in prostaglandin E2-induced pancreatic beta-cell dysfunction. Endocrinology.
150: 5284-93.
12）Meng ZX, Nie J, Ling JJ, Sun JX, Zhu YX, Gao L, Lv JH, Zhu DY, Sun YJ, Han X (2009) Activation of liver X receptors inhibits pancreatic islet
beta cell proliferation through cell cycle arrest.Diabetologia. 52: 125-35.
13）Meng ZX, Sun JX, Ling JJ, Lv JH, Zhu DY, Chen Q, Sun YJ, Han X (2006) Prostaglandin E2 regulates Foxo activity via the Akt pathway:
implications for pancreatic islet beta cell dysfunction. Diabetologia. 49: 2959-68.
14）Xu ZK, Chen NG, Ma CY, Meng ZX, Sun YJ, Han X (2006) Role of peroxisome proliferator-activated receptor gamma in glucose-induced
insulin secretion. Acta Biochim Biophys Sin. 38: 1-7.
代表性学术报告：
1）The Sixth Scientific Meeting of the Chinese-American Diabetes Association (CADA) Oral presentation: Glycolytic muscle metabolism
and glucose homeostasis Boston, MA, 4-5 Jun. 2015
2）Invited seminar: Role of chromatin remodeling factors in metabolic control and diseases National University of Defense Technology,
Changsha, China, 24 Oct, 2014
3）Invited seminar: Role of chromatin remodeling factors in metabolic control and diseases Nanjing Normal University, Nanjing, China, 10 Sep. 2014
4）The Muscle Microenvironment: A niche for the next generation of biomedical scientists Invited speaker: Glycolytic muscle: metabolic plasticity
and its role in energy homeostasis The Ohio State University, OH, 12 May. 2014
5）The Fifth Scientific Meeting of the Chinese-American Diabetes Association (CADA)
Oral presentation: BAF60c drives glycolytic muscle formation and improves glucose homeostasis through Deptor-mediated AKT
activation.Chicago, IL, 20-21 Jun. 2013
6）Colloquium of Life Sciences Institute, University of Michigan
Oral presentation: BAF60c drives glycolytic muscle formation and improves glucose homeostasis through Deptor-mediated AKT activation.
Ann Arbor,MI, 24 Jan. 2012
7）Obesity, Diabetes and Metabolic Diseases Club, University of Michigan
Oral presentation: Metabolic properties of skeletal myofiber: specification and physiology.Ann Arbor, MI, 10 Mar. 2011